Congratulations! Bono and Ephrussi labs publish in Nature Struc Mol Biol and Nature Comm.

Exu-Paper-2016-copyrightThe group of Fulvia Bono published a structure-to-functional analysis of the bicoid mRNA-localization factor Exuperantia (Exu) from Drosophila. Their crystal structure shows that Exu forms a dimer and that each subunit consists of a catalytically inactive 3’-5’ EXO domain and a SAM domain. Both domains are required for binding to a highly structured region in the 3’UTR of the bicoid transcript. Thus, Exu is a non-canonical RNA-binding protein.

Lazzaretti D, Veith K, Kramer K, Basquin C, Urlaub H, Irion U, Bono F.
The bicoid mRNA localization factor Exuperantia is an RNA-binding pseudonuclease.
Nat Struct Mol Biol. 2016 Jul 4. doi: 10.1038/nsmb.3254.


Sysoev-etal-RBPThe group of Anne Ephrussi used a very different approach to study mRNA localization in the fruit fly. In this study, all RNA-interacting proteins were mapped before and after maternal-to-zygotic transition of early embryogenesis. From the over 500 detected factors about half of them had not been described before as RNA-binding proteins. Furthermore the comparison of both datasets indicates that the RNA-bound proteome is highly dynamic during early developmental stages.

Sysoev VO, Fischer B, Frese CK, Gupta I, Krijgsveld J, Hentze MW, Castello A, Ephrussi A.
Global changes of the RNA-bound proteome during the maternal-to-zygotic transition in Drosophila.
Nat Commun. 2016 Jul 5;7:12128. doi: 10.1038/ncomms12128.

First FOR2333 meeting on March 1.- 2. in Blaubeuren

Our first meeting of the DFG Research Unit 2333 (FOR2333) took place on March 1st and 2nd in the guesthouse of the University Tübingen in Blaubeuren. We enjoyed our first get-together with excellent discussions and talks. Looking forward to our next meeting taking place in Düsseldorf on September 5th to 7th, again focusing on ‘macromolecular complexes in mRNA localization’…


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DFG decision: FOR2333 Research Unit will be funded!

Our DFG Research Unit 2333 on „mRNA localization“ just received a positive funding decision from the DFG. We are excited and look forward to start our network. More details will follow soon…  (October 15th 2015)

Press releases: Tuebingen University / Duesseldorf University / LMU Munich


 

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