Zarnack lab

ZarnackThe Zarnack lab uses computational methods to study the molecular mechanisms of posttranscriptional regulation. A main focus of the group is the description of critical regulatory decisions and the characterisation of the responsible RNA-binding proteins (RBPs) from a genomic perspective. We participate in the FOR2333 Research Unit with the following project:

Project 1: We will develop new computational tools to reliably detect RBP binding sites from genome-wide binding data and comprehensively characterise their RNA sequence and structure features to understand the molecular code of RNA recognition. In collaboration with the Niessing, Jansen, Kiebler and Ephrussi labs, we will exploit the newly established analysis workflows to learn more about the She mRNA transport complex in yeast, the translational regulator Pumilio2 in mammalian neurons and the exon-junction complex in fruit flies.

Selected publications by the Zarnack lab:

  • Haberman et al. Genome Biol 18(1): 7 (2017) [pubmed]
  • Murn et al. Nat Struct Mol Biol 23: 16-23 (2016) [pubmed]
  • Murn et al. Genes Dev 29: 501-12 (2015) [pubmed]
  • Zarnack et al. Cell 152: 453-66 (2013) [pubmed]
  • König et al. Nat Struct Mol Biol 17: 909-15 (2010) [pubmed]

Contact:

Buchmann Institute for Molecular Life Sciences (BMLS)
Goethe Universität Frankfurt
Max-von-Laue-Str. 15, 60438 Frankfurt
kathi.zarnack[at]bmls.de
Website at Goethe University Frankfurt

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