Our research group at the Max Planck Institute for Developmental Biology in Tübingen is focused on the nuclear transport of mRNP components. We aim at the understanding of the molecular mechanisms underlying mRNA localization and translational control by an interdisciplinary approach that combines biochemistry, structural biology as well as cell- and organism-based functional assays.
We contribute to the FOR2333 Research Unit with a project in collaboration with the lab of Anne Ephrussi to biochemically characterize localized mRNPs in Drosophila. Our objective is to expand the complement of factors involved in mRNA localization and pave the way for future structural and functional studies.
Selected publications by the Bono lab on this topic:
- Lazzaretti et al. Nat Struct Mol Biol doi: 10.1038/nsmb.3254 (2016) [pubmed]
- Kinkelin et al. RNA 18: 1624-34 (2012) [pubmed]
- Bono et al. Mol Cell 37: 211-22 (2010) [pubmed]
- Bono et al. Cell 126: 713-27 (2006) [pubmed]
Max Planck Insitute for Developmental Biology,