FOR2333 members participate in “The RNA Localization and Local Translation Conference” in Snowmass, Colorado

Group picture at "The RNA Localization and Local Translation Conference", SnowmassMembers of the FOR2333 network participated in “The RNA Localization and Local Translation Conference” in Snowmass, United States. The conference took place from June 30th to July 5th 2019 in Snowmass Village, a beautiful mountain resort in Colorado, and was packed with great talks and exciting science.  Thanks to the organizers for this wonderful meeting!

RNA transport meeting from March 3rd to 6th 2018 in Düsseldorf-Kaiserswerth

From March 3rd to 6th 2018 our RNA transport meeting took place in Düsseldorf-Kaiserswerth, where various experts from a broad field of RNA biology were representing the current state of the mRNA-localization field.
It was a very exciting congress with outstanding keynote lectures and 9 sessions packed with excellent talks. Of course, we also had lots of fun!






Staufen2 critically contributes to working memory in the rat

At the cellular level, learning and memory rely on the physical modification of synapses, which are ultimately encoded by transported mRNAs and protein synthesis “onsite”. In previous studies, Michael Kiebler and his team have shown that the RNA-binding protein Staufen2 is essential in conveying mRNAs to their destinations. Now, a new study carried out by the Kiebler group and colleagues shows that reduced levels of Staufen2 are associated with a specific impairment of memory. Using a genetic model in which Staufen2 can be conditionally and selectively suppressed in nerve cells in the rat forebrain, they observed that Staufen2 depletion affected nerve-cell morphology, synaptic function and impaired spatial, temporal and associative memory. The findings appear in the journal Genome Biology.


Stefan M. Berger, Iván Fernández-Lamo, Kai Schönig, Sandra M. Fernández Moya, Janina Ehses, Rico Schieweck, Stefano Clementi, Thomas Enkel, Sascha Grothe, Oliver von Bohlen und Halbach, Inmaculada Segura, José María Delgado-García, Agnès Gruart, Michael A. Kiebler and Dusan Bartsch.
Forebrain-specific, conditional silencing of Staufen2 alters synaptic plasticity, learning and memory in rats.
Genome Biology 2017 Nov 17;18(1):222. doi: 10.1186/s13059-017-1350-8.



New review by three FOR2333 labs on mRNA localization in fungal species

The Niessing, Jansen and Feldbrügge labs published a review on recent advances in mRNA localization in different fungal species. The review appeared in WIREs RNA and puts a special focus on the comparison of membrane-free and membrane-bound RNA transport.

Niessing, Jansen, Pohlmann & Feldbrügge
mRNA transport in fungal top models
WIREs RNA DOI: 10.1002/wrna.1453 (2017) 

You can find a wrap-up of this article on the website of [Advanced Science News].



Feldbrügge lab publishes a novel link between long-distance endosomal transport and endocytic traffic

In particular in highly polarized cells like fungal hyphal early endosomes carry out two distinct functions. Firstly, during endocytosis they function as transport unit to deliver cargo towards the lysosome/vacuole. Secondly, the same early endosomes are used to deliver cargo like mRNAs, associated ribosomes as well as protein complexes over long distances to ensure efficient polar growth. Studying the evolutionarily conserved protein Did2 revealed that this ESCRT regulator is needed to coordinate these two seemingly independent functions. This has implications for the role of early endosomes in other trafficking processes like during neuronal mRNA transport.  

Haag, C., Pohlmann, T., Feldbrügge, M.
The ESCRT regulator Did2 maintains the balance between long-distance endosomal transport and endocytic trafficking.
PLoS Genet 13(4): e1006734 (2017).